Samira "Sam", a pessimistic, terminally ill cancer patient, lives at a hospice outside New York City with her cat, Frodo. Reuben, a nurse, convinces a reluctant Sam to join a group outing to a marionette show in Manhattan. While in the city, the group notices meteor-like objects falling from the sky. Shortly afterwards, hostile extraterrestrial creatures attack the gathered crowd and passersby. A creature hits a noisy ambulance, and the explosion knocks Sam unconscious